Are there any drug interactions associated with consuming mangosteen?

Taking mangosteen together with medications that also slow blood clotting could increase the risk of bruising and bleeding. They are blueberry, gogi, mangosteen, noni, acai, pomegranate and sea buckthorn. When most of us think of juice, we think of “healthy and safe”, but when these 7 are consumed in large quantities they can have very powerful effects on the body. These effects can be good or bad, depending on the situation.

There are no significant drug interactions; use with caution with anticoagulants. The pharmacokinetic change (PK) of a drug caused by the concomitant administration of herbal products may alter efficacy and toxicity. In circumstances where more and more attempts are being made to combine herbs and medications to alleviate Alzheimer's disease (AD), pharmacological evaluation of the interaction between herbs and drugs (IDH) is necessary. The change in systemic exposure, as well as in the distribution of the drug in target tissue, have been published in HDI.

Recently, the memory-improving effects of the aqueous extract of the mangosteen pericarp (WMP) have been described, suggesting the possibility of combining WMP and donepezil (DNP) for the treatment of AD. Therefore, we evaluated how WMP affects the pharmacokinetic change of donepezil, including systemic exposure and tissue distribution in mice after simultaneous oral administration of DNP with WMP. First, the combined treatment of WMP and donepezil showed a stronger inhibitory effect (23.0%) on Abeta-induced neurotoxicity (25-3) in SH-SY5Y neuroblastoma cells than donepezil alone, suggesting that the combination of WMP and donepezil may be more effective in moderating neurotoxicity than donepezil alone. In the drug interaction, WMP increased the concentration of donepezil in the brain 4 h (63.6%) after administration without affecting systemic exposure to donepezil.

Taken together, our results suggest that WMP could be used in combination with DNP as a treatment for AD. Mangosteen is a tropical plant native to Southeast Asia. The fruits are consumed as food and are also used in traditional medicine to treat skin infections, wounds and diarrhea. Mangosteen juice is marketed as a healthy drink and the pericarp, or fruit peel, is used in dietary supplements because of its antioxidant activity.

Preliminary data show that xanthones, bioactive compounds in mangosteen, have antibacterial (, antifungal), anti-inflammatory (), anti-atherosclerotic (2), anti-angiogenic (2), anti-angiogenic (2), cytotoxic (1), aromatase inhibitory (1) and anticancer (1) properties. They may also provide protection against doxorubicin-induced neurotoxicity (1) and cisplatin-induced nephrotoxicity (1).

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