Mangosteen is a tropical plant native to Southeast Asia, and its fruits are consumed as food and used in traditional medicine. The juice is marketed as a healthy drink, and the pericarp, or fruit peel, is used in dietary supplements due to its antioxidant activity. Xanthones, bioactive compounds in mangosteen, have been found to have antibacterial, antifungal, anti-inflammatory, anti-atherosclerotic, anti-angiogenic, cytotoxic, aromatase inhibitory, anticancer, and neuroprotective properties. When it comes to drug interactions, taking mangosteen together with medications that slow blood clotting could increase the risk of bruising and bleeding.
Therefore, it is important to use caution when taking anticoagulants with mangosteen. Recently, the memory-improving effects of the aqueous extract of the mangosteen pericarp (WMP) have been described. This suggests that combining WMP and donepezil (DNP) may be more effective in moderating neurotoxicity than donepezil alone. In drug interaction studies, WMP increased the concentration of donepezil in the brain 4 hours after administration without affecting systemic exposure to donepezil.
In conclusion, mangosteen has many potential health benefits due to its antioxidant activity and bioactive compounds. However, it is important to be aware of potential drug interactions when taking medications that slow blood clotting. Additionally, combining WMP and donepezil may be more effective in moderating neurotoxicity than donepezil alone.
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